São Vicente (after Saint Vincent of Saragossa, the patron Saint of Lisbon, Portugal) is a coastal municipality in southern São Paulo, Brazil. It is part of the Metropolitan Region of Baixada Santista. The population is 355,542. São Vicente is located on the western half of coastal São Vicente Island, being mostly a bedroom community for the larger and wealthier neighboring port and commercial city of Santos on the island’s eastern half
It was the first permanent Portuguese settlement in the Americas and the first capital of the Captaincy of São Vicente, roughly the present state of São Paulo. Established as a proper village in 1532 by Martim Afonso de Sousa on what was then the Porto dos Escravos (“Port of the Slaves”), operated by three Portuguese colonists who trafficked on slaves captured by allied tribes, São Vicente is titled Cellula Mater (Mother Cell) of Brazil for being the first organized town in the country.